Description
Product Name: LGD-4033
Synonyms: Ligandrol
CAS: 1165910-22-4
MF: C14H12F6N2O
MW: 338.25
EINECS: 1806241-263-5
Melting point 108 – 111°C
Boiling point 439.9±45.0 °C
density 1.45±0.1 g/cm3
What is LGD-4033 ?
LGD-4033 is a selective androgen receptor modulator. It is a compound that targets specific androgen receptors in the body. Its main function can increase muscle growth and bone density. It was originally developed for the treatment of muscle atrophy and bone density. Disorders such as osteoporosis, discovered by Ligand Pharmaceuticals and currently being developed by Viking Therapeutics, many studies have confirmed that LGD-4033 can help build muscle mass without a lot of side effects, and it is not highly depressive like testosterone, which means you can Cycle without worrying about long-term downtime.
(1) Before clinical medical use
In 13 weeks, the daily dose of 0 to 75mg/kg was given to male and female cynomolgus monkeys. Both of them had a significant increase in body weight, but after 48 days, the dose was significantly higher than that used in phase 2 clinical trials. The 75 mg/kg dosing test was discontinued, but this did not negatively affect animal development.
(2) Clinical trials
In the phase 1 clinical trial of 76 adult males, through the observation of different supply doses, the change of users’ net body weight gain was positively correlated with the supply dose, and there were no obvious side effects under the 21-day test.
The Phase 2 clinical trial started on November 3, 2015, administered to 120 patients after hip fracture surgery. The subjects were divided into receiving placebo and different doses of LGD-4033 during the 12-week test process. Observation of net body weight change, quality of life, safety and pharmacokinetics all showed satisfactory results.
Is LGD-4033 safe ?
In the past few years, many studies have pointed out that LGD-4033 has little toxicity to the body, the subjects’ net body weight (muscle) and bone density have increased, and when taken for a long time, it will slightly inhibit the autologous testis Solid secretion.
The side effects part of it, the relevant research shows not much, LGD does not seem to cause any hair loss or male pattern baldness, in clinical trials, it was shown that the prostate size was not affected, and also because all SARMs are not converted into estrogen, so LGD-4033 will not cause the problem of gynecomastia.
What can be expected to be obtained by using LGD-4033 ?
(1) Helps prevent osteoporosis:
LGD-4033 has a positive effect on BMD by increasing periosteal bone formation, which helps maintain bone mass while reducing muscle loss.
(2) Prevention of cancer or malignant disease (Cachexia):
Malignancies are known to be very common in patients suffering from cancer, AIDS, and kidney disease, among others. By using this you will be able to prevent it from happening, as LGD-4033 is known for increasing muscle mass and enhancing muscle strength. In this way, it can reduce the chance of developing malignant disease in these individuals.
(3) Increase muscle mass:
Want to get a muscular body? Getting better muscle mass with this is very easy now. This is because the supplement will allow your body to experience increased energy production and blood circulation, which can play a greater role in muscle building.
(4) Increase body energy:
One of the key functions of this is to increase body metabolism, meaning that your body will be able to burn a lot of fat, which is converted into energy, which can also improve other body functions, such as breathing and digestion.
(5) Contribute to fat loss:
LGD-4033 has also been found to play an important role in enhancing weight loss, as it works by improving muscle strength, which means your body burns more calories and when they are converted into energy, it creates more energy. There is a large calorie deficit, and at the same time, it can protect muscles from being broken down during fat loss.
(6) Increase muscle strength:
In the case of LGD-4033, preventing any muscle loss that can lead to osteoporosis, it works by strengthening bone density and also gains in strength due to increased energy in the body.
(7) Improve sexual life performance:
Many erectile dysfunctions, such as premature ejaculation, can be addressed by taking LGD-4033, which will have a positive impact on your sex life.
(8) Some body changes before and after use for reference:
Many users of LGD-4033 start noticing significant results after four weeks of use, one of the biggest changes will be in your muscle mass, taking just 1mg of the supplement it will increase by about 2.66 lbs. The higher the dose, the greater the gain, but this should never exceed the recommended dose without adverse effects.
There are also significant gains in strength and endurance, not only reported by clinical trials, but also by other athletes who have used SARMs. You’ll find that weight training is less strenuous and can significantly increase your workout time, allowing you to work out more for better muscle gains.
Significantly increases workout time, allowing you to work out more for better muscle gains.
Another noteworthy change is body fat, you should notice a loss of fat, which will be replaced by muscle mass, and if you stack LGD-4033 with other SARMS, the effect of fat loss will be more significant.
Frequently asked questions :
(1) At what point in time was LGD-4033 used ?
It doesn’t matter when you take it. Some people like to use it before exercise. In fact, it only needs to be used at a fixed time every day. Others are personal preferences.
(2) Does LGD-4033 suppress gonads ?
To some extent, yes, LGD-4033 will suppress natural testosterone production; having said that, if you’re on a dose of about 10mg and don’t exceed 60 days, there shouldn’t be a major problem. And if depression occurs, it can also be easily resolved by performing PCT.
(3) Is PCT required ?
As mentioned above, this is worth discussing, for light doses and short cycles, you should be able to recover naturally without PCT. Regardless, after your cycle is over, running PCT not only can’t hurt, it can boost your testosterone levels, which is good for building muscle or preserving gains.
(4) Will LGD-4033 cause drowsiness ?
This can indeed happen over long periods of use, but I’ve never experienced it personally. If you feel lethargic, it may be due to a slight suppression of your gonadal axis.
(5) How long does it take to feel the effect of LGD-4033 ?
For most people, it usually takes about a week for LGD-4033 to start to feel, including strength, training pump, etc., but it may vary from person to person, but usually a week is a common time.
(6) It can be used with LGD-4033 with other things
It depends on your goal, if you want
For muscle gain, it can be stacked with MK-677, YK-11 and Ostarine (MK-2866).
If you want to lose fat, it is recommended to reduce the dose of LGD-4033 to 5 mg per day and stack it with cardarine (GW-1516) and ostarine (MK-2866).
Of course, when LGD-4033 is stacked with steroids, the effect is also quite good.
(7) Will LGD-4033 increase estrogen ?
Not at all, keep in mind that LGD-4033 is a SARM, not a steroid, it does not cause the body to react in the same way as steroids or precursors, and therefore does not produce breast milk.
Conclusion :
Diet and exercise are the most important part of achieving your fitness goals before deciding to use LGD-4033, LGD-4033 will help you reach your goals, but if your diet control is pretty bad, it is still useless.
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