Description
Product Name: RAD140
Synonyms: Testolone
CAS: 1182367-47-0
MF: C20H16ClN5O2
MW: 393.83
EINECS: 1592732-453-0
Melting point: 179-183oC
Boiling point: 687.7±65.0 °C
Density: 1.41±0.1 g/cm3
Storage temp: -20°C Freezer
Solubility Chloroform (Slightly), DMSO (Slightly)
Introduction :
RAD 140 is an orally bioavailable non-steroidal selective androgen receptor modulator (SARM) that increases muscle mass and enhances the effects of testosterone without the undesirable effects of anabolic steroids side effect.
Early studies and user reviews have shown better results than using steroids with minimal side effects, making it one of the most exciting and powerful SARMs to date. Read on for a comprehensive overview of everything you need to know about RAD 140, including benefits, side effects, research and results for increasing muscle mass and maintaining gains.
History :
RAD140 is currently in development by the pharmaceutical company Radius. Its original findings were originally published in 2010, meaning research has been limited. However, preliminary studies, company reports, and anecdotal user reviews are very promising for building muscle without the side effects of anabolic steroids.
It was discovered through an internal discovery program that Testolone is actually being developed to treat breast cancer and muscle wasting in postmenopausal women. The FDA accepted their Investigational New Drug Application, and the first human clinical trials are expected to begin in 2017.
How the RAD140 works :
The androgen receptor (AR) is primarily targeted for normal human sexual development, but its activation by compounds such as testosterone also affects bone, muscle, liver and central nervous system.
The issue within the medical and bodybuilding community is that using testosterone to activate AR signaling to increase muscle and bone development also affects sexual tissue, leading to testicular shrinkage, female clitoris enlargement and even prostate cancer risk.
RAD140, a non-steroidal selective androgen receptor modulator (SARM), bypasses this problem. Because of the way RAD140 binds to the androgen receptor, different cells respond by releasing different proteins, and only some of the androgen receptors are activated throughout the body.
This stimulation results in the activation of androgen receptors in bone and muscle cells, rather than raising liver enzymes or affecting sexual tissues.
Benefits :
1. RAD140 Helps Increase Muscle Mass
The number one benefit of supplementing with RAD140 is the ability to increase lean mass without gaining fat. In fact, in preliminary studies with monkeys, scientists observed an average weight gain of more than 10 percent in just 28 days. This is done using only RAD 140 and without any of the unwanted side effects traditionally associated with testosterone.
2. RAD140 can improve speed, stamina and stamina during high-intensity training
Want to work out longer, harder, and get better results every time you hit the gym? Reports of increased speed, stamina, and stamina during workouts are common when supplemented with Testolone. Plus, high-intensity training and interval training can be optimized every time thanks to its ability to build muscle tissue and reduce fat.
3. RAD140 is more anabolic than testosterone
Similar to other SARMs such as LGD4033 (Ligandrol) or S4 (Andarine), RAD140 produces similar results to testosterone but without the side effects.
RAD140 interacts with the hormone receptors of muscle and bone tissue in the same way that high doses of testosterone do, all without the estrogenic side effects caused by anabolic steroids.
Many users on forums have also reported greater anabolic effects than testosterone, and are sometimes used as PCT for steroid users to preserve muscle mass between cycles.
4. RAD140 can reduce the side effects of testosterone
When used in combination with anabolic steroids, preliminary studies have shown that RAD140 reduces the side effects of testosterone stimulation on the prostate and seminal vesicles of monkeys
Additionally, many anabolic steroid users report concerns about their liver health. However, during the 28-day trial, the doses in these monkeys had significantly lower liver enzyme elevations than the 10-fold full effective dose, even while gaining body weight over a short period of time (which can cause liver strain)
5. Since the results of RAD140 have proven to be better than anabolic steroid use, users may be better off forgetting about testosterone altogether and sticking with SARMs.
Testosterone appears to have no reproductive side effects of anabolic steroids
Preliminary studies in mice found that low doses of RAD140 were needed to stimulate muscle growth without affecting prostate weight.
This means that RAD140 is able to selectively stimulate muscle and bone growth while reducing the impact on sexual tissues such as the prostate or the clitoris. (yes, that means RAD140 is safe for women)
6. RAD140 may aid in weight loss by increasing fat loss
RAD140 indirectly reduces body fat by increasing muscle and bone cells, which are more metabolically expensive to maintain than fat cells. By increasing muscle mass, an increase in metabolism can be seen, making it easier to lose weight [3].
Because of RAD140’s ability to increase stamina, stamina, and speed during interval training, users can also report increased muscle growth and reduced fat storage.
7. RAD140 is being tested in breast cancer
RAD140 was discovered and is currently being developed by pharmaceutical company Radius specifically for the treatment of androgen receptor (AR) and estrogen receptor positive (ER+) breast cancer in postmenopausal women.
In vitro studies completed in 2017 showed that RAD140 inhibits the growth of AR/ER+ breast cancer cells. The results of these studies support further investigation of RAD140 as a breast cancer therapy and suggest the first human clinical trial [4].
8. RAD140 considered neuroprotective for brain health in neurodegenerative diseases
As testosterone levels decline in men, there is an increased risk of disease in androgen-responsive tissues, including the brain, implying the development of neurodegenerative diseases such as Alzheimer’s disease.
However, treating AR disease with testosterone may increase the risk of prostate cancer. Recent studies suggest that RAD140 may be as effective as testosterone at reducing cell death, with no side effects on the prostate.
Side effects :
As with most SARMs, research shows that RAD140 does not appear to have any of the side effects that are common with steroids. Unlike testosterone, RAD140 does not cause prostate enlargement or testicular shrinkage.
However, since it’s still in its early developmental stages, that doesn’t mean there aren’t long-term effects. Some user-reported side effects include headaches or insomnia that go away with the correct dosage.
Dosage Guidelines :
Testosterone research is still being studied, but it is known to have the same potency and effectiveness as LGD4033.
Studies in male primates have shown that 20-30mg per day every 24-36 hours is optimal for maximum skeletal hypertrophy, which is consistent with anecdotal testimonies from users. Safety has been studied for up to 12 weeks, but developmental trials may show tolerance up to 24 weeks.
Notably, RAD140 systemically regulates the neuroexcitatory amino acid kainate, which activates glutamate receptors in the brain. The role of kainic acid in nerve cell death, especially in the hippocampus, has been shown to be a major cause of Alzheimer’s disease. RAD140 has shown positive results in preventing kainic acid production, and a medical study published by the Endocrine Society showed that RAD140 can improve brain health through neuroprotective properties in as little as 13 days
Although safe for women, lower doses are recommended. Women are advised to take 5 mg per day, with a daily limit of no more than 10 mg.
Although there is no official human dose of RAD140, its potency and effectiveness have been compared with LGD4033.
Current research shows that it can be tolerated for up to 12 weeks of use. We recommend that you do not exceed this 12 weeks for best results.
Rad140 vs Ostarine :
Ostarine is by far SARM’s most popular and successful product. It is used for a wide range of fitness goals. Many athletes include Ostarine in their diets to improve their athletic performance and enhance their muscular appearance.
This compound is known for its amazing cutting ability. It shreds your body fat super fast, allowing muscles to retain their muscle mass. The results are very similar to anabolic steroids, but without the accompanying side effects. This means you don’t need to worry about compromising your liver or heart health. Also, it does not cause problems like high blood pressure, gynecomastia, hair loss, acne, mood swings, and libido issues.
When it comes to fitness goals, the RAD 140 works very similarly to the Ostarine. Not only does it help build lean muscle mass, it also significantly increases strength levels. Also, it is a great tool for cutting purposes and building stamina. It can also be used to improve athletic performance.
However, this compound is slightly potent for beginners, so it is recommended that they choose Ostarine first before trying RAD 140.
If your fitness goals include bulking, then RAD 140 is definitely a better choice as it is more powerful than Ostarine in this case. You can expect to gain significant muscle mass within 8 to 12 weeks of your cycle. However, results will vary between individuals, but everyone will experience a considerable increase in lean muscle mass with RAD 140.
This compound lacks androgenic effects, which is a good thing because you don’t need to worry about things like gynecomastia, hair loss, acne, liver toxicity, and high blood pressure.
The cutting results of RAD 140 and Ostarine are very similar. However, the RAD 140 does a better job of maintaining stubborn muscle and strength levels during the cutting phase. This is mainly due to the high anabolic ratio of this compound.
Stack :
The RAD140, while good, can be stacked with other SARMs to suit your individual needs.
Many users report stacking RAD140 (Testolone) with MK677 (Nutrobal) and MK2866 (Ostarine) for a boost in building muscle, burning fat, boosting growth hormone, joint recovery, and improving sleep.
Testosterone is especially beneficial for older users, who can reduce muscle loss, joint health and restore sleep.
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